I-PRF - Injection of Plasma Rich Fibrin and Hair loss

What could be better than repairing yourself with a Tissue Auto Rejuvenation process using Injectable-Fibrin-Rich Plasma (I-PRF).

I-Prf is the 100% biocompatible cutaneous bio-revitalization treatment that has a direct action on dermal cells, resulting in a visible renewal of the skin.

The treatment begins with a blood sample, in a dry tube without chemical additive (contrary to the PRP), which is centrifuged according to a specific protocol to obtain a concentration of growth factors in a fibrin network. These active ingredients will be slowly released into the skin for maximum effectiveness.

This treatment is done either in needle mesotherapy or mesopen.

The regeneration of an injected area means the creation of a new cellular tissue complete with fibroblasts which will manufacture new collagen fibers, new micro-vessels to provide the necessary nutrients to these new cells and also new epidermal cells. This will help restore elasticity, firmness to the skin and a boost of radiance to the complexion.

Platelets are blood cells which, when stimulated, produce cytokines. These cytokines are intercellular messengers essential for proper cell function and renewal such as growth factors or interleukins.

The growth factors produced by platelets are among others:

• FGF (Fibroblast Growth Factor): stimulates the secretion of collagen by fibroblasts.
• EGF (epidermal Growth Factor): stimulates healing and regeneration of the epidermis.
• VEGF (vascular Growth Factor): stimulates the creation of new vascularization to allow the arrival of stem cells for tissue renewal.
• TGF b1 (Transforming Growth Factor): induces the synthesis of collagen type 1.
• PDGF-ab (Platlet Growth Factor): regulates the migration and survival of stem cells.
• IGF (Insulin Growth Factor): cell protective agent.

Other cytokines include:

• TNF-alpha (Tumor Necrosis Factor-alpha): stimulates the remodeling of fibroblasts.
• IL 1 (InterLeukine1): increases collagen synthesis by fibroblasts and limits the production of protein degrading enzymes.

Growth factors help bio-stimulate the cells in the injected area to promote natural cell regeneration. But for it to be fully beneficial, it must persist over time. And this is where the difference between PRP and I-PRF comes in.

PRP and I-PRF are two activated platelet concentrates, but PRP releases growth factors immediately and at once, limiting their beneficial effects in time. On the other hand, I-PRF traps these growth factors within a fibrin network which will be released slowly as the fibrin is naturally and gradually resorbed over a period of 28 days. It is a real bath of youth for your cutaneous and subcutaneous stem cells.

A simple blood test can collect a few milliliters of blood. The centrifugation mode that will follow is different from that of PRP, in order to preserve the precious fibrin in addition to the platelet-rich plasma concentrate. This centrifugation concentrates platelets 5 to 7 times more than in circulating blood.

I-PRF collection tubes differ from PRP. They are free of chemical additives which eliminates the risk of foreign body reaction or allergy.

The I-PRF is then quickly injected into the desired areas. The depth of injection depends on the purpose of the treatment. Local anesthesia with topical cream is desirable when using the Dermapen for the "Vampire lift".

The number and spacing of sessions depends on age and skin condition. For a young person, in prevention, this will be an annual session. For more marked people, a protocol can be set up with 3 sessions spaced from one to 3 months apart, then maintenance sessions at 6 months. The persistent effect of 6 months to a year, it is good to renew the sessions regularly.

I-PRF allows progressive tissue remodeling thanks to platelet growth factors which, by stimulating stem cells, relaunch the formation of new cutaneous and subcutaneous structures.

To bio-stimulate the superficial dermis, we will inject intradermally using a syringe or the Dermapen as for a mesotherapy session; the objective being texture, hydration and skin radiance.

Injected into the deep dermis or subdermally, the I-PRF will have a filling purpose with the usual volume losses as an indication. The action will be bio-restructuring and dermal volumizing.

The objective is to :

• Bio-regenerate the skin of the face, neck, décolleté and back of the hands.
• Treat perioral wrinkles.
• Treat emerging wrinkles.
• Improve beginner dark circles.
• Improve volume losses.
• Fight against hair loss.

An equation sums up its effects

i-Prf= skin effects + hair effects

the skin effects translates into skin rejuvenation with an improved texture of the dermis allowing smoothing of fine lines and imperfections, skin tone regained, a brighter complexion and a smooth skin feel.

The hair effect in the equation reminds us that i-Prf is the new effective treatment for hair loss. A noticeable slowing down of hair loss occurs and regrowth appears with increased hair density and thickening of the hair which will also be more silky and shiny. These effects make it possible to extend the hair indications to dull, brittle, devitalized hair and to preserve the hair capital.

The few contraindications are pregnancy, breastfeeding, autoimmune and blood diseases and cancer.

The suites are simple. In the case of deep injection, they are comparable to those of an injection of filler, such as a slight inflammatory reaction possible for 48 to 72 hours. In the case of more superficial treatment such as the "Vampire lift", small crusts easily covered by a CC-cream may persist for a few days.

This new bio-stimulant treatment can be used alone or in addition to filler injections for the rejuvenation of cutaneous and subcutaneous tissues. This is another important step in the range of complementary techniques made available to doctors and patients for the management of skin aging and its rejuvenation.

Also read the Monaco Matin article about the I-PRF (click on the image below to download the PDF file):